作者
Jonathan P Singer, Eric R Peterson, Mark E Snyder, Patricia P Katz, Jeffrey A Golden, Frank D’Ovidio, Matthew Bacchetta, Joshua R Sonett, Jasleen Kukreja, Lori Shah, Hilary Robbins, Kristin Van Horn, Rupal J Shah, Joshua M Diamond, Nancy Wickersham, Li Sun, Steven Hays, Selim M Arcasoy, Scott M Palmer, Lorraine B Ware, Jason D Christie, David J Lederer
发表日期
2014/11/1
期刊
American journal of respiratory and critical care medicine
卷号
190
期号
9
页码范围
1012-1021
出版商
American Thoracic Society
简介
Rationale: Obesity and underweight are contraindications to lung transplantation based on their associations with mortality in studies performed before implementation of the lung allocation score (LAS)–based organ allocation system in the United States
Objectives: To determine the associations of body mass index (BMI) and plasma leptin levels with survival after lung transplantation.
Methods: We used multivariable-adjusted regression models to examine associations between BMI and 1-year mortality in 9,073 adults who underwent lung transplantation in the United States between May 2005 and June 2011, and plasma leptin and mortality in 599 Lung Transplant Outcomes Group study participants. We measured body fat and skeletal muscle mass using whole-body dual X-ray absorptiometry in 142 adult lung transplant candidates.
Measurements and Main Results: Adjusted mortality rates were similar among …
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