作者
Aaron Kassoff, Sheldon M Buzney, J Wallace McMeel, John J Weiter, Gerald J Doyle, Rodney L Immerman, Gerald R Friedman, Michael L Klein, Richard Dreyer, Richard Chenoweth, Irvin Handelman, Richard Hohl, Robert Biesbroeck, Jack Sipperley, Charles A Garcia, Michael A Bloome, Richard S Ruiz, F Tempel Riekhof, William A Bohart, Roy A Goodart, Dana H Clarke, David H Orth, Timothy P Flood, Kirk H Packo, Jayant Malhotra, Akbar Rahmani, Edward J Winter, Harish Bhatia, Robert P Murphy, Stuart L Fine, Michael J Elman, Frederick L Ferris, Thaddeus E Prout, Arnall Patz, Thomas A Rice, David Newsome, Lloyd M Aiello, Lawrence I Rand, Sabera T Shah, Ramachandiran Cooppan, Jerry Cavallerano, Robert Poole, Philip Silver, Jose Briones, Mohammed Z Wafai, Abdul C Asmal, Rudolph M Franklin, Laurence Arend, Donald Bergsma, Lance Turkish, Paul Beer, Denis Carroll, Edgar Thomas, Thomas C Burton, Gary W Abrams, Hak-Joong Kim, George A Williams, Trexler M Topping, Frederick H Reeser, Thomas M Aaberg, Gregory S Brinton, James K Kingham, Travis A Meredith, Raymond R Margherio, Patrick L Murphy, Morton S Cox, Michael Trese, Steven Winokur, Everett Ai, Robert Sorenson, Gary Arsham, John Cavender, Stanley M Kopelow, Alan L Shabo, Jose C Briones, Richard D Hornichter, Norman P Blair, Morton F Goldberg, C Ronald Lindberg, Neil L Ross, Lynn E Hauser, Jose Cunha-Vaz, J Terry Ernest, James C Liang, Steven B Cohen, Charles Vygantas, Gerald Williams, Harry W Flynn, George W Blankenship, William H Knobloch, Robert C Ramsay, Herbert L Cantrill, Frederick C Goetz, Byron Hoogwerf, José Berrocal, Raúl Pérez, A Ramos Umpierre, James L Kinyoun, Robert E Kalina, Craig G Wells, Steven V Guzak, Jerry Palmer, Frank L Myers, George H Bresnick, Suresh R Chandra, Matthew D Davis, Ronald Klein, Thomas S Stevens, Ingolf H Wallow, Russell Dixon, Edward Ehrlich, Robin Ewart, Robert N Frank, Stephenie Lucas, Fred Whitehouse, Harold Weiss, Ann E Ballen, Michael Teske, Maria Warth, William E Benson, William S Tasman, Gary C Brown, J Archibald McNamara, Hunter L Little, Robert L Jack, Lawrence Basso, Dayton T Miller, Elaine Gunter, David D Bayse, W Harry Hannon, James E Myrick, Genell L Knatterud, Marian R Fisher, Mary Jane Prior, Franca Barton, Joseph Kufera, Thomas W Miller, James K Hooper, Richard S Crow, Richard R Baker, Ronald Prineas, Larry D Hubbard, Yvonne L Magli, Paul Segal, Richard L Mowery, Emily Y Chew, Daniel G Seigel, Gary Cassel
发表日期
1992/9/9
期刊
Jama
卷号
268
期号
10
页码范围
1292-1300
出版商
American Medical Association
简介
Objectives
—This report presents information on the effects of aspirin on mortality, the occurrence of cardiovascular events, and the incidence of kidney disease in the patients enrolled in the Early Treatment Diabetic Retinopathy Study (ETDRS).
Study Design
—This multicenter, randomized clinical trial of aspirin vs placebo was sponsored by the National Eye Institute.
Patients
—Patients (N=3711) were enrolled in 22 clinical centers between April 1980 and July 1985. Men and women between the ages of 18 and 70 years with a clinical diagnosis of diabetes mellitus were eligible. Approximately 30% of all patients were considered to have type I diabetes mellitus, 31% type II, and in 39% type I or II could not be determined definitely.
Intervention
—Patients were randomly assigned to aspirin or placebo (two 325-mg tablets once per day).
Main Outcome Measures
—Mortality from all causes was specified as the primary …
引用总数
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A Kassoff, SM Buzney, JW McMeel, JJ Weiter, GJ Doyle… - Jama, 1992