作者
Sajid A Khan, Melinda Morris, Kamran Idrees, Mark I Gimbel, Shoshana Rosenberg, Zhaoshi Zeng, Fangyong Li, Geliang Gan, Jinru Shia, Michael P LaQuaglia, Philip B Paty
发表日期
2016/11/1
期刊
Journal of pediatric surgery
卷号
51
期号
11
页码范围
1812-1817
出版商
WB Saunders
简介
Introduction
Colorectal cancer (CRC) diagnosed before age 30 years is a fatal disease whose biology remains poorly understood. To understand its pathogenesis, we compared molecular and clinical data in surgically treated early-age onset and adult onset patients.
Materials and Methods
Clinical data and tumor tissue were collected retrospectively for 94 patients with early-age onset CRC (age ≤ 30 years) and compared to 275 adult CRC patients (age ≥ 50 years). Tumor morphology, microsatellite instability (MSI) and stability (MSS), KRAS and BRAF mutations, and mismatch repair (MMR) expression (MSH2, MLH1, MSH6, PMS2) were assessed.
Results
Early-age CRC was distinguished from adult CRC by advanced stage presentation (P < 0.001), frequent high grade cancers (P < 0.001), and poor prognosis (P < 0.001). MSI was associated with favorable survival and MMR loss in both groups. Compared to …
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SA Khan, M Morris, K Idrees, MI Gimbel, S Rosenberg… - Journal of pediatric surgery, 2016