作者
Xiaowei Jiang, Xu Dai, Elliot Kale Edmiston, Qian Zhou, Ke Xu, Yifang Zhou, Feng Wu, Lingtao Kong, Shengnan Wei, Yuning Zhou, Miao Chang, Haiyang Geng, Dahai Wang, Ye Wang, Wenhui Cui, Fei Wang, Yanqing Tang
发表日期
2017/10/15
期刊
Journal of affective disorders
卷号
221
页码范围
297-303
出版商
Elsevier
简介
Background
It is often difficult to differentiate major depressive disorder (MDD) and bipolar disorder (BD) merely according to clinical symptoms. Similarities and differences in neural activity between the two disorders remain unclear. In current study, we use amplitude of low-frequency fluctuations (ALFF) to compare neural activation changes between MDD and BD patients.
Methods
One hundred and eighty-three adolescents and young adults (57 MDD, 46 BD and 80 healthy controls, HC) were scanned during resting state. The ALFF for each participant was calculated, and were then compared among all groups using voxel-based analysis.
Results
There was a significant effect of diagnosis in the core regions of cortico-limbic-striatal neural system. Furthermore, MDD showed left-sided abnormal neural activity while BD showed a bilateral abnormality in this neural system.
Limitations
This study was underpowered to …
学术搜索中的文章
X Jiang, X Dai, EK Edmiston, Q Zhou, K Xu, Y Zhou… - Journal of affective disorders, 2017