作者
Jerry W Shay, Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa, Maryam Goudarzi, Albert J Fornace, Saleh Baeesa, Deema Hussain, Mohammed Bangash, Fahad Alghamdi, Hans-Juergen Schulten, Angel Carracedo, Ishaq Khan, Hanadi Qashqari, Nawal Madkhali, Mohamad Saka, Kulvinder S Saini, Awatif Jamal, Jaudah Al-Maghrabi, Adel Abuzenadah, Adeel Chaudhary, Mohammed Al Qahtani, Ghazi Damanhouri, Heba Alkhatabi, Anne Goodeve, Laura Crookes, Nikolas Niksic, Nicholas Beauchamp, Adel M Abuzenadah, Jim Vaught, Bruce Budowle, Mourad Assidi, Abdelbaset Buhmeida, Jaudah Al-Maghrabi, Abdelbaset Buhmeida, Mourad Assidi, Leena Merdad, Sudhir Kumar, Sayaka Miura, Karen Gomez, Angel Carracedo, Mahmood Rasool, Ahmed Rebai, Sajjad Karim, Hend F Nour Eldin, Heba Abusamra, Elham M Alhathli, Nada Salem, Mohammed H Al-Qahtani, Sudhir Kumar, Hossam Faheem, Ashok Agarwa, Eberhard Nieschlag, Joachim Wistuba, Oliver S Damm, Mohd A Beg, Taha A Abdel-Meguid, Hisham A Mosli, Osama S Bajouh, Adel M Abuzenadah, Mohammed H Al-Qahtani, Serdar Coskun, Muhammad Abu-Elmagd, Abdelbaset Buhmeida, Ashraf Dallol, Jaudah Al-Maghrabi, Sahar Hakamy, Wejdan Al-Qahtani, Asia Al-Harbi, Shireen Hussain, Mourad Assidi, Mohammed Al-Qahtani, Adel Abuzenadah, Burak Ozkosem, Rick DuBois, Safia S Messaoudi, Maryam T Dandana, Touhami Mahjoub, Wassim Y Almawi, S Abdalla, M Nabil Al-Aama, Asmaa Elzawahry, Tsuyoshi Takahashi, Sachiyo Mimaki, Eisaku Furukawa, Rie Nakatsuka, Isao Kurosaka, Takahiko Nishigaki, Hiromi Nakamura, Satoshi Serada, Tetsuji Naka, Seiichi Hirota, Tatsuhiro Shibata, Katsuya Tsuchihara, Toshirou Nishida, Mamoru Kato, Sajid Mehmood, Naeem Mahmood Ashraf, Awais Asif, Muhammad Bilal, Malik Siddique Mehmood, Aadil Hussain, Qazi Mohammad Sajid Jamal, Mughees Uddin Siddiqui, Mohammad A Alzohairy, Mohammad A Al Karaawi, Taoufik Nedjadi, Jaudah Al-Maghrabi, Mourad Assidi, Heba Al-Khattabi, Adel Al-Ammari, Ahmed Al-Sayyad, Abdelbaset Buhmeida, Mohammed Al-Qahtani, Hédia Zitouni, Nozha Raguema, Marwa Ben Ali, Wided Malah, Raja Lfalah, Wassim Almawi, Touhami Mahjoub, Mohammed Elanbari, Andrey Ptitsyn, Sana Mahjoub, Rabeb El Ghali, Bechir Achour, Nidhal Ben Amor, Mourad Assidi, Brahim N’siri, Hamid Morjani, Taoufik Nedjadi, Adel Al-Ammari, Ahmed Al-Sayyad, Nada Salem, Esam Azhar, Jaudah Al-Maghrabi, Vera Chayeb, Maryam Dendena, Hedia Zitouni, Khedija Zouari-Limayem, Touhami Mahjoub, Bassem Refaat, Ahmed M Ashshi, Sarah A Batwa, Hazem Ramadan, Amal Awad, Ahmed Ateya
发表日期
2016/7
期刊
BMC genomics
卷号
17
页码范围
1-78
出版商
BioMed Central
简介
The ends of linear chromosomes are called telomeres that resemble broken DNA. However, the telomeres are protected from the DNA damage responses due to the formation of a looping structure (T-loop) and by “capping” the telomeres with a series of shelterin proteins. It is generally thought the main, if not only, function of telomeres is protection from DNA damage responses. When telomeres get very short due to normal replicative aging, cells stop dividing due to loss of the telomere end protective functions. We have previously reported that telomeres may also have additional functions in human cells. Telomeres are characterized by a distinct chromatin structure with spreading of heterochromatin into the subtelomeric regions, but little is known about the chromatin conformation of human telomeres. We have previously shown, using a luciferase reporter introduced into telomeres, that there is a 10-fold decreased …
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JW Shay, N Homma, R Zhou, MI Naseer… - BMC genomics, 2016