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Background: Age and ethnicity are important factors in breast cancer (BC) disparities and outcome. However, studies examining both racial and age-related disparities are scarce. We sought to determine differences in epidemiological and clinicopathological characteristics of breast cancer between races in age-specific cohorts. Methods: Gulf Centre for Cancer Registration database and King Faisal Specialist Hospital and Research Center BC registry database for Saudi/Arab women (n=4,206) and Cancer Incidence in Five Continents Volume XI reports, and Surveillance, Epidemiology, and End Results for African-American and non-Hispanic White women with BC were used. Results: Early onset BC (age < 50 years) was more prevalent among Arab women (63%) compared with African-American women (29%) and White-American women (21%). Young Arab and African-American women had more estrogen …