作者
Colin R Zamecnik, Gavin M Sowa, Ahmed Abdelhak, Ravi Dandekar, Rebecca D Bair, Kristen J Wade, Christopher M Bartley, Kerry Kizer, Danillo G Augusto, Asritha Tubati, Refujia Gomez, Camille Fouassier, Chloe Gerungan, Colette M Caspar, Jessica Alexander, Anne E Wapniarski, Rita P Loudermilk, Erica L Eggers, Kelsey C Zorn, Kirtana Ananth, Nora Jabassini, Sabrina A Mann, Nicholas R Ragan, Adam Santaniello, Roland G Henry, Sergio E Baranzini, Scott S Zamvil, Joseph J Sabatino Jr, Riley M Bove, Chu-Yueh Guo, Jeffrey M Gelfand, Richard Cuneo, H-Christian von Büdingen, Jorge R Oksenberg, Bruce AC Cree, Jill A Hollenbach, Ari J Green, Stephen L Hauser, Mitchell T Wallin, Joseph L DeRisi, Michael R Wilson
发表日期
2024/4/19
期刊
Nature Medicine
页码范围
1-9
出版商
Nature Publishing Group US
简介
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody profiles of hundreds of patients with MS (PwMS) years before and subsequently after MS onset. This analysis defines a unique cluster in approximately 10% of PwMS who share an autoantibody signature against a common motif that has similarity with many human pathogens. These patients exhibit antibody reactivity years before developing MS symptoms and have higher levels of serum neurofilament light (sNfL) compared to other PwMS. Furthermore, this profile is preserved over time, providing molecular evidence for an immunologically active preclinical period years before clinical onset. This autoantibody reactivity was …
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CR Zamecnik, GM Sowa, A Abdelhak, R Dandekar… - Nature Medicine, 2024