作者
Ahmed Abdelhak, Pascal Benkert, Sabine Schaedelin, W John Boscardin, Christian Cordano, Johanna Oechtering, Kirtana Ananth, Cristina Granziera, Lester Melie-Garcia, Shivany Condor Montes, Alexandra Beaudry-Richard, Lutz Achtnichts, Frederike C Oertel, Patrice H Lalive, David Leppert, Stefanie Müller, Roland G Henry, Caroline Pot, Amandine Matthias, Anke Salmen, Jorge R Oksenberg, Giulio Disanto, Chiara Zecca, Marcus D’Souza, Renaud Du Pasquier, Claire Bridel, Claudio Gobbi, Ludwig Kappos, Stephen L Hauser, Bruce AC Cree, Jens Kuhle, Ari J Green, MS EPIC UCSF, Sergio Baranzini, Riley Bove, Michael Wilson, Jill Hollenbach, Refujia Gomez, Adam Santaniello, Meagan Harms, Tiffany Cooper, Stacy Caillier, Johannes Lorscheider, Alessandro Cagol, Muhamed Barakovic, Riccardo Galbusera, Özgür Yaldizli, Suvitha Subramaniam, Annette Orleth, Tobias Derfuss, Aleksandra Maleska Maceski, Eline Willemse, Lars G Hemkens, Perrine Janiaud, Lilian Demuth, Bettina Fischer-Barnicol, Robert Hoepner, Andrew Chan, Oliver Findling
发表日期
2023/12/1
期刊
JAMA neurology
卷号
80
期号
12
页码范围
1317-1325
出版商
American Medical Association
简介
Importance
Mechanisms contributing to disability accumulation in multiple sclerosis (MS) are poorly understood. Blood neurofilament light chain (NfL) level, a marker of neuroaxonal injury, correlates robustly with disease activity in people with MS (MS); however, data on the association between NfL level and disability accumulation have been conflicting.
Objective
To determine whether and when NfL levels are elevated in the context of confirmed disability worsening (CDW).
Design, Setting, and Participants
This study included 2 observational cohorts: results from the Expression, Proteomics, Imaging, Clinical (EPIC) study at the University of California San Francisco (since 2004) were confirmed in the Swiss Multiple Sclerosis Cohort (SMSC), a multicenter study in 8 centers since 2012. Data were extracted from EPIC in April 2022 (sampling July 1, 2004, to December 20, 2016) and SMSC in December 2022 (sampling …
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A Abdelhak, P Benkert, S Schaedelin, WJ Boscardin… - JAMA neurology, 2023