作者
Ludmila Prokunina, Leonid Padyukov, Anna Bennet, Ulf De Faire, Björn Wiman, Jonathan Prince, Lars Alfredsson, Lars Klareskog, Marta Alarcón‐Riquelme
发表日期
2004/6
期刊
Arthritis & Rheumatism: Official Journal of the American College of Rheumatology
卷号
50
期号
6
页码范围
1770-1773
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
To study the frequency of allele A of polymorphism PD‐1.3 of the PDCD1 gene in patients with rheumatoid arthritis (RA) and its subsets, based on the presence of rheumatoid factor (RF) and the shared epitope (SE) alleles.
Methods
A total of 1,175 patients with RA and 3,404 controls were genotyped for the PD‐1.3 A/G polymorphism, which previously was identified as being involved in susceptibility to systemic lupus erythematosus (SLE) in patients of European descent.
Results
We first detected a trend for association of allele A of the single‐nucleotide polymorphism PD‐1.3 with RA (P = 0.053, odds ratio [OR] 1.18, 95% confidence interval [95% CI] 0.99–1.41). To further clarify the nature of this association, patients with RA were divided into 4 groups according to the presence of RF and the SE alleles. Association was found only in the group of patients negative for both RF and the SE alleles (P = 0 …
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L Prokunina, L Padyukov, A Bennet, U De Faire… - Arthritis & Rheumatism: Official Journal of the American …, 2004