作者
Peter J Vuillermin, Martin O’Hely, Fiona Collier, Katrina J Allen, Mimi LK Tang, Leonard C Harrison, John B Carlin, Richard Saffery, Sarath Ranganathan, Peter D Sly, Lawrence Gray, John Molloy, Angela Pezic, Michael Conlon, David Topping, Karen Nelson, Charles R Mackay, Laurence Macia, Jennifer Koplin, Samantha L Dawson, Margarita Moreno-Betancur, Anne-Louise Ponsonby, J. Craig Venter Institute Vashee Sanjay 9 Torralba Manolito 9 Gomez Andres 9, BIS Investigator Group Dwyer Terrence 3 Burgner David 3 Forrester Michael 1 2 Symeonides Christos 3 Bandala Sanchez Esther 6
发表日期
2020/3/24
期刊
Nature communications
卷号
11
期号
1
页码范围
1452
出版商
Nature Publishing Group UK
简介
In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus that produces short chain fatty acids and endotoxins, each of which may promote the development of fetal immune tolerance. In this study, we use a prebirth cohort (n = 1064 mothers) to conduct a nested case-cohort study comparing 58 mothers of babies with clinically proven food IgE mediated food allergy with 258 randomly selected mothers. Analysis of the V4 region of the 16S rRNA gene in fecal samples shows maternal carriage of Prevotella copri during pregnancy strongly predicts the absence of food allergy in the offspring. This association was confirmed using targeted qPCR and was independent of infant carriage of P. copri. Larger household size, which is …
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PJ Vuillermin, M O'Hely, F Collier, KJ Allen, MLK Tang… - Nature communications, 2020