作者
Pierre‐Antoine Dugué, Julie K Bassett, JiHoon E Joo, Chol‐Hee Jung, EE Ming Wong, Margarita Moreno‐Betancur, Daniel Schmidt, Enes Makalic, Shuai Li, Gianluca Severi, Allison M Hodge, Daniel D Buchanan, Dallas R English, John L Hopper, Melissa C Southey, Graham G Giles, Roger L Milne
发表日期
2018/4/15
期刊
International journal of cancer
卷号
142
期号
8
页码范围
1611-1619
简介
The association between aging and cancer is complex. Recent studies have developed measures of biological aging based on DNA methylation and called them “age acceleration.” We aimed to assess the associations of age acceleration with risk of and survival from seven common cancers. Seven case–control studies of DNA methylation and colorectal, gastric, kidney, lung, prostate and urothelial cancer and B‐cell lymphoma nested in the Melbourne Collaborative Cohort Study were conducted. Cancer cases, vital status and cause of death were ascertained through linkage with cancer and death registries. Conditional logistic regression and Cox models were used to estimate odds ratios (OR) and hazard ratios (HR) and 95% confidence intervals (CI) for associations of five age acceleration measures derived from the Human Methylation 450 K Beadchip assay with cancer risk (N = 3,216 cases) and survival (N …
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PA Dugué, JK Bassett, JHE Joo, CH Jung… - International journal of cancer, 2018