作者
Uri Neri, Yuri I Wolf, Simon Roux, Antonio Pedro Camargo, Benjamin Lee, Darius Kazlauskas, I Min Chen, Natalia Ivanova, Lisa Zeigler Allen, David Paez-Espino, Donald A Bryant, Devaki Bhaya, Adrienne B Narrowe, Alexander J Probst, Alexander Sczyrba, Annegret Kohler, Armand Séguin, Ashley Shade, Barbara J Campbell, Björn D Lindahl, Brandi Kiel Reese, Breanna M Roque, Chris DeRito, Colin Averill, Daniel Cullen, David AC Beck, David A Walsh, David M Ward, Dongying Wu, Emiley Eloe-Fadrosh, Eoin L Brodie, Erica B Young, Erik A Lilleskov, Federico J Castillo, Francis M Martin, Gary R LeCleir, Graeme T Attwood, Hinsby Cadillo-Quiroz, Holly M Simon, Ian Hewson, Igor V Grigoriev, James M Tiedje, Janet K Jansson, Janey Lee, Jean S VanderGheynst, Jeff Dangl, Jeff S Bowman, Jeffrey L Blanchard, Jennifer L Bowen, Jiangbing Xu, Jillian F Banfield, Jody W Deming, Joel E Kostka, John M Gladden, Josephine Z Rapp, Joshua Sharpe, Katherine D McMahon, Kathleen K Treseder, Kay D Bidle, Kelly C Wrighton, Kimberlee Thamatrakoln, Klaus Nusslein, Laura K Meredith, Lucia Ramirez, Marc Buee, Marcel Huntemann, Marina G Kalyuzhnaya, Mark P Waldrop, Matthew B Sullivan, Matthew O Schrenk, Matthias Hess, Michael A Vega, Michelle A O’malley, Monica Medina, Naomi E Gilbert, Nathalie Delherbe, Olivia U Mason, Paul Dijkstra, Peter F Chuckran, Petr Baldrian, Philippe Constant, Ramunas Stepanauskas, Rebecca A Daly, Regina Lamendella, Robert J Gruninger, Robert M McKay, Samuel Hylander, Sarah L Lebeis, Sarah P Esser, Silvia G Acinas, Steven S Wilhelm, Steven W Singer, Susannah S Tringe, Tanja Woyke, TBK Reddy, Terrence H Bell, Thomas Mock, Tim McAllister, Vera Thiel, Vincent J Denef, Wen-Tso Liu, Willm Martens-Habbena, Xiao-Jun Allen Liu, Zachary S Cooper, Zhong Wang, Mart Krupovic, Valerian V Dolja, Nikos C Kyrpides, Eugene V Koonin, Uri Gophna
发表日期
2022/10/13
期刊
Cell
卷号
185
期号
21
页码范围
4023-4037. e18
出版商
Elsevier
简介
High-throughput RNA sequencing offers broad opportunities to explore the Earth RNA virome. Mining 5,150 diverse metatranscriptomes uncovered >2.5 million RNA virus contigs. Analysis of >330,000 RNA-dependent RNA polymerases (RdRPs) shows that this expansion corresponds to a 5-fold increase of the known RNA virus diversity. Gene content analysis revealed multiple protein domains previously not found in RNA viruses and implicated in virus-host interactions. Extended RdRP phylogeny supports the monophyly of the five established phyla and reveals two putative additional bacteriophage phyla and numerous putative additional classes and orders. The dramatically expanded phylum Lenarviricota, consisting of bacterial and related eukaryotic viruses, now accounts for a third of the RNA virome. Identification of CRISPR spacer matches and bacteriolytic proteins suggests that subsets of picobirnaviruses …
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