作者
Therese Truong, Rayjean J Hung, Christopher I Amos, Xifeng Wu, Heike Bickeböller, Albert Rosenberger, Wiebke Sauter, Thomas Illig, H-Erich Wichmann, Angela Risch, Hendrik Dienemann, Rudolph Kaaks, Ping Yang, Ruoxiang Jiang, John K Wiencke, Margaret Wrensch, Helen Hansen, Karl T Kelsey, Keitaro Matsuo, Kazuo Tajima, Ann G Schwartz, Angie Wenzlaff, Adeline Seow, Chen Ying, Andrea Staratschek-Jox, Peter Nürnberg, Erich Stoelben, Jürgen Wolf, Philip Lazarus, Joshua E Muscat, Carla J Gallagher, Shanbeh Zienolddiny, Aage Haugen, Henricus FM Van Der Heijden, Lambertus A Kiemeney, Dolores Isla, Jose Ignacio Mayordomo, Thorunn Rafnar, Kari Stefansson, Zuo-Feng Zhang, Shen-Chih Chang, Jin Hee Kim, Yun-Chul Hong, Eric J Duell, Angeline S Andrew, Flavio Lejbkowicz, Gad Rennert, Heiko Müller, Hermann Brenner, Loïc Le Marchand, Simone Benhamou, Christine Bouchardy, M Dawn Teare, Xiaoyan Xue, John McLaughlin, Geoffrey Liu, James D McKay, Paul Brennan, Margaret R Spitz
发表日期
2010/7/7
期刊
Journal of the National Cancer Institute
卷号
102
期号
13
页码范围
959-971
出版商
Oxford University Press
简介
Background
Genome-wide association studies have identified three chromosomal regions at 15q25, 5p15, and 6p21 as being associated with the risk of lung cancer. To confirm these associations in independent studies and investigate heterogeneity of these associations within specific subgroups, we conducted a coordinated genotyping study within the International Lung Cancer Consortium based on independent studies that were not included in previous genome-wide association studies.
Methods
Genotype data for single-nucleotide polymorphisms at chromosomes 15q25 (rs16969968, rs8034191), 5p15 (rs2736100, rs402710), and 6p21 (rs2256543, rs4324798) from 21 case–control studies for 11 645 lung cancer case patients and 14 954 control subjects, of whom 85% were white and 15% were Asian, were pooled. Associations between the variants and the risk of …
学术搜索中的文章
T Truong, RJ Hung, CI Amos, X Wu, H Bickeböller… - Journal of the National Cancer Institute, 2010