作者
J Michael Schmidt, Sang-Bae Ko, Raimund Helbok, Pedro Kurtz, R Morgan Stuart, Mary Presciutti, Luis Fernandez, Kiwon Lee, Neeraj Badjatia, E Sander Connolly, Jan Claassen, Stephan A Mayer
发表日期
2011/5
期刊
Stroke
卷号
42
期号
5
页码范围
1351-1356
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
To identify a minimally acceptable cerebral perfusion pressure threshold above which the risks of brain tissue hypoxia (BTH) and oxidative metabolic crisis are reduced for patients with subarachnoid hemorrhage (SAH).
Methods
We studied 30 poor-grade SAH patients who underwent brain multimodality monitoring (3042 hours). Physiological measures were averaged over 60 minutes for each collected microdialysis sample. Metabolic crisis was defined as a lactate/pyruvate ratio >40 with a brain glucose concentration ≤0.7 mmol/L. BTH was defined as PbtO2 <20 mm Hg. Outcome was assessed at 3 months with the Modified Rankin Scale.
Results
Multivariable analyses adjusting for admission Hunt-Hess grade, intraventricular hemorrhage, systemic glucose, and end-tidal CO2 revealed that cerebral perfusion pressure ≤70 mm Hg was significantly associated with an increased risk of BTH …
学术搜索中的文章
JM Schmidt, SB Ko, R Helbok, P Kurtz, RM Stuart… - Stroke, 2011
