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At the time of this manuscript going to press, Europe remains the epicenter of the COVID-19 pandemic and new cases and deaths in the UK continue to demonstrate an exponential rise. 1 London has the highest number of reported UK cases. 2 Clinical reports indicate that older adults with comorbidities such as diabetes and hypertension are most at risk of severe COVID-19. 3, 4 Overwhelming inflammation and cytokine associated lung injury are potential pathological features. Secondary hemophagocytic lymphohistiocytosis-like syndrome with raised pro-inflammatory cytokines has been associated with adverse outcomes. 5 King’s College Hospital is a teaching hospital in South London, caring for approximately 500 adults and 500 children with sickle cell disease (SCD). South London currently has some of the highest numbers of confirmed cases of COVID-19 in England2 and a large local SCD cohort. It is …