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Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with complex aetiology and phenotypes. Phosphodiesterase10A (PDE10A) has been shown to provide benefits in various brain conditions. We investigated the role of papaverine, a selective PDE10A inhibitor on core phenotypes in prenatal alcohol exposure (PAE) model of ADHD. In order to identify probable mechanisms involved, the effects on several protein markers of neuronal function such as, neuronal survival‐BDNF, neuronal transcription factor‐pCREB, brain inflammation (IL‐6, IL‐10, and TNF‐α), and brain oxidative stress (TBARS and GSH) were studied in frontal cortex, cerebellum, and striatum. PAE resulting hyper‐locomotion, inattention, and anxiety were studied by the use of open‐field, y‐maze, and elevated plus maze, respectively. Administration of papaverine (15/30 mg kg⁻¹) to PAE group of animals resulted in …