作者
Ali A Mehdi, Imad Uthman, Munther Khamashta
发表日期
2010/5
来源
European journal of clinical investigation
卷号
40
期号
5
页码范围
451-464
出版商
Blackwell Publishing Ltd
简介
Eur J Clin Invest 2010; 40 (5): 451–464
Abstract
Background Antiphospholipid syndrome (APS) is a systemic autoimmune vascular disease characterized by recurrent thrombotic episodes and/or obstetric complications. Management of this disease has been restricted mainly to anticoagulation; however, in recent years, significant advancement has been made in elucidating the pathophysiology of the disease including antiphospholipid antibody (aPL)‐induced activation of the platelets, endothelial cells, monocytes, complement and coagulation cascade. Stemming from these advances, potential targeted therapeutic approaches have been proposed.
Materials and methods We utilized a computer‐assisted search of the literature (MEDLINE, National Library of Medicine, Bethesda, MD, USA) up until September 2009 using the keywords: antiphospholipid syndrome, antiphospholipid antibodies, anticardiolipin …
学术搜索中的文章
AA Mehdi, I Uthman, M Khamashta - European journal of clinical investigation, 2010