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Both obesity and depression are diseases of civilization with a high clinical and scientific relevance. Correlations between both diseases usually turn out to be very complex and are not always applicable to all affected patients to the same extent. Especially, dysregulations of neuroimmunological parameters and physiological regulatory processes play an important role in the development and maintenance of both obesity and mood disorders. Due to the complexity of the underlying mechanisms it is difficult to apply standardized interventions for patients in clinical practice. Therapeutic measures should always be applied in the context of current research and adapted to the individual situation of the patient.