作者
Micaela Ebert, Adrianus P Wijnmaalen, Marta de Riva, Serge A Trines, Alexander FA Androulakis, Claire A Glashan, Martin J Schalij, J Peter van Tintelen, Jan DH Jongbloed, Katja Zeppenfeld
发表日期
2020/9/1
期刊
Clinical Electrophysiology
卷号
6
期号
9
页码范围
1103-1114
出版商
American College of Cardiology Foundation
简介
Objectives
This study aimed to assess the frequency of (likely) pathogenic variants (LP/Pv) among dilated cardiomyopathy (DCM) ventricular tachycardia (VT) patients referred for CA and their impact on procedural outcome and long-term prognosis.
Background
The prevalence of genetic variants associated with monomorphic VT among DCM is unknown.
Methods
Ninety-eight consecutive patients (age 56 ± 15 years; 84% men, left ventricular ejection fraction [LVEF] 39 ± 12%) referred for DCM-VT ablation were included. Patients underwent electroanatomical mapping and testing of ≥55 cardiomyopathy-related genes. Mapping data were analyzed for low-voltage areas and abnormal potentials. LP/Pv-positive (LP/Pv+) patients were compared with LP/Pv-negative (LP/Pv–) patients and followed for VT recurrence and mortality.
Results
In 37 (38%) patients, LP/Pv were identified, most frequently LMNA (n = 11 of …
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M Ebert, AP Wijnmaalen, M de Riva, SA Trines… - Clinical Electrophysiology, 2020