作者
Odilon Nouatin, Javier Ibáñez, Rolf Fendel, Ulysse A Ngoa, Freia-Raphaella Lorenz, Jean-Claude Dejon-Agobé, Jean Ronald Edoa, Judith Flügge, Sina Brückner, Meral Esen, Michael Theisen, Stephen L Hoffman, Kabirou Moutairou, Adrian JF Luty, Bertrand Lell, Peter G Kremsner, Ayola A Adegnika, Benjamin Mordmüller
发表日期
2022/6/17
期刊
Malaria Journal
卷号
21
期号
1
页码范围
191
出版商
BioMed Central
简介
Background
Antibody and cellular memory responses following vaccination are important measures of immunogenicity. These immune markers were quantified in the framework of a vaccine trial investigating the malaria vaccine candidate GMZ2.
Methods
Fifty Gabonese adults were vaccinated with two formulations (aluminum Alhydrogel and CAF01) of GMZ2 or a control vaccine (Verorab). Vaccine efficacy was assessed using controlled human malaria infection (CHMI) by direct venous inoculation of 3200 live Plasmodium falciparum sporozoites (PfSPZ Challenge). GMZ2-stimulated T and specific B-cell responses were estimated by flow cytometry before and after vaccination. Additionally, the antibody response against 212 P. falciparum antigens was estimated before CHMI by protein microarray.
Results
Frequencies of pro- and anti-inflammatory CD4+ T cells stimulated with the vaccine antigen GMZ2 as well as B …
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O Nouatin, J Ibáñez, R Fendel, UA Ngoa, FR Lorenz… - Malaria Journal, 2022