作者
Benjamin Mordmüller, Christian Supan, Kim Lee Sim, Gloria P Gómez-Pérez, Carmen Lucelly Ospina Salazar, Jana Held, Stefanie Bolte, Meral Esen, Serena Tschan, Fanny Joanny, Carlos Lamsfus Calle, Sascha JZ Löhr, Albert Lalremruata, Anusha Gunasekera, Eric R James, Peter F Billingsley, Adam Richman, Sumana Chakravarty, Almudena Legarda, Jose Muñoz, Rosa M Antonijoan, Maria Rosa Ballester, Stephen L Hoffman, Pedro L Alonso, Peter G Kremsner
发表日期
2015/12
期刊
Malaria journal
卷号
14
页码范围
1-11
出版商
BioMed Central
简介
Background
Controlled human malaria infection (CHMI) accelerates development of anti-malarial interventions. So far, CHMI is done by exposure of volunteers to bites of five mosquitoes carrying Plasmodium falciparum sporozoites (PfSPZ), a technique available in only a few centres worldwide. Mosquito-mediated CHMI is logistically complex, exact PfSPZ dosage is impossible and live mosquito-based interventions are not suitable for further clinical development.
Methods
An open-labelled, randomized, dose-finding study in 18–45 year old, healthy, malaria-naïve volunteers was performed to assess if intravenous (IV) injection of 50 to 3,200 aseptic, purified, cryopreserved PfSPZ is safe and achieves infection kinetics comparable to published data of mosquito-mediated CHMI. An independent study site verified the fully infectious dose using direct venous …
学术搜索中的文章
B Mordmüller, C Supan, KL Sim, GP Gómez-Pérez… - Malaria journal, 2015
