作者
Dorothee Kieninger, Eric Sheldon, Wen-Yuan Lin, Chong-Jen Yu, Jose M Bayas, Julian J Gabor, Meral Esen, Jose Luis Fernandez Roure, Silvia Narejos Perez, Carmen Alvarez Sanchez, Yang Feng, Carine Claeys, Mathieu Peeters, Bruce L Innis, Varsha Jain
发表日期
2013/12
期刊
BMC infectious diseases
卷号
13
页码范围
1-13
出版商
BioMed Central
简介
Background
Two antigenically distinct influenza B lineages have co-circulated since the 1980s, yet inactivated trivalent influenza vaccines (TIVs) include strains of influenza A/H1N1, A/H3N2, and only one influenza B from either the Victoria or Yamagata lineage. This means that exposure to B-lineage viruses mismatched to the TIV is frequent, reducing vaccine protection. Formulations including both influenza B lineages could improve protection against circulating influenza B viruses. We assessed a candidate inactivated quadrivalent influenza vaccine (QIV) containing both B lineages versus TIV in adults in stable health.
Methods
A total of 4659 adults were randomized 5:5:5:5:3 to receive one dose of QIV (one of three lots) or a TIV containing either a B/Victoria or B/Yamagata strain. Hemagglutination-inhibition assays were performed pre-vaccination and …
学术搜索中的文章
D Kieninger, E Sheldon, WY Lin, CJ Yu, JM Bayas… - BMC infectious diseases, 2013