作者
James Whitehorn, Duong Thi Hue Kien, Nguyet Minh Nguyen, Hoa L Nguyen, Peter P Kyrylos, Lauren B Carrington, Chau Nguyen Bich Tran, Nguyen Thanh Ha Quyen, Long Vo Thi, Dui Le Thi, Nguyen Thanh Truong, Tai Thi Hue Luong, Chau Van Vinh Nguyen, Bridget Wills, Marcel Wolbers, Cameron P Simmons
发表日期
2015/10/15
期刊
The Journal of infectious diseases
卷号
212
期号
8
页码范围
1182-1190
出版商
Oxford University Press
简介
Aedes albopictus is secondary to Aedes aegypti as a vector of dengue viruses (DENVs) in settings of endemicity, but it plays an important role in areas of dengue emergence. This study compared the susceptibility of these 2 species to DENV infection by performing 232 direct blood-feeding experiments on 118 viremic patients with dengue in Vietnam. Field-derived A. albopictus acquired DENV infections as readily as A. aegypti after blood feeding. Once infected, A. albopictus permitted higher concentrations of DENV RNA to accumulate in abdominal tissues, compared with A. aegypti. However, the odds of A. albopictus having infectious saliva were lower than the odds observed for A. aegypti (odds ratio, 0.70; 95% confidence interval, .52–.93). These results quantitate the susceptibility of A. albopictus to DENV infection and will assist parameterization of models for predicting disease risk in settings where …
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J Whitehorn, DTH Kien, NM Nguyen, HL Nguyen… - The Journal of infectious diseases, 2015