作者
Justas Dapkūnas, Kliment Olechnovič, Česlovas Venclovas
发表日期
2018/3/1
期刊
Proteins: Structure, Function, and Bioinformatics
卷号
86
期号
S1
页码范围
292-301
简介
We participated in Round 37 of the Critical Assessment of PRediction of Interactions (CAPRI), held jointly with the 12th edition of the Critical Assessment of protein Structure Prediction (CASP12), having two major objectives. First, we intended to test the utility of our PPI3D web server in finding and selecting templates for comparative modeling of structures of protein complexes. Our second aim was to evaluate the ability of our model accuracy estimation method VoroMQA to score and rank structural models for protein‐protein interactions. Using sequence search in PPI3D and HHpred servers we identified multimeric templates for 7 of 11 CAPRI targets, and models of at least acceptable quality were constructed for 6 of them. The clustering and visual analysis features implemented in the PPI3D software were instrumental in detecting alternative protein‐protein interaction interfaces among the identified templates …
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