作者
Justas Dapkūnas, Kliment Olechnovič, Česlovas Venclovas
发表日期
2021/12
期刊
Proteins: Structure, Function, and Bioinformatics
卷号
89
期号
12
页码范围
1834-1843
出版商
John Wiley & Sons, Inc.
简介
The goal of CASP experiments is to monitor the progress in the protein structure prediction field. During the 14th CASP edition we aimed to test our capabilities of predicting structures of protein complexes. Our protocol for modeling protein assemblies included both template‐based modeling and free docking. Structural templates were identified using sensitive sequence‐based searches. If sequence‐based searches failed, we performed structure‐based template searches using selected CASP server models. In the absence of reliable templates we applied free docking starting from monomers generated by CASP servers. We evaluated and ranked models of protein complexes using an improved version of our protein structure quality assessment method, VoroMQA, taking into account both interaction interface and global structure scores. If reliable templates could be identified, generally accurate models of protein …
引用总数
20212022202320243264
学术搜索中的文章
J Dapkūnas, K Olechnovič, Č Venclovas - Proteins: Structure, Function, and Bioinformatics, 2021