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Glomerular disease, be it primary or secondary, occurring in the setting of systemic autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In most kidney failure registries, glomerular diseases account for about 20%–25% of the prevalent cases. However, in children, teenagers, and young adults, glomerular disease is one of the most common causes of irreversible kidney damage and, as such, is not only a source of personal suffering but also a major socioeconomic problem. In 2012, KDIGO published its first-ever guideline on the management of glomerular diseases. In the 8 years that have passed, several major discoveries have been made that relate to our understanding of the pathogenesis, diagnosis, and therapy of glomerular disease. The unequivocal proof that primary membranous nephropathy is an autoimmune disease, the uncovering of the role of complement in …