作者
SS Laurentino, Patricia IS Pinto, J Tomas, JE Cavaco, M Sousa, A Barros, DM Power, Adelino VM Canário, S Socorro
发表日期
2013/6
期刊
Andrologia
卷号
45
期号
3
页码范围
187-194
简介
The androgen receptor (AR) is a ligand‐activated transcription factor member of the nuclear receptor superfamily. The existence of alternatively spliced variants is well recognised for several members of this superfamily, most of them having functional importance. For example, several testicular oestrogen receptor variants have been suggested to play a role in the regulation of spermatogenesis. However, information on AR variants is mostly related to cancer and androgen insensitivity syndrome (AIS) cases. The objective of this study was to investigate the expression of AR variants in the testis from humans and other vertebrates. Four AR variants [ARΔ2Stop, ARΔ223Stop, ARΔ3 and ARΔ4(120)] were identified in human testis. ARΔ2Stop and ARΔ3, with exon 2 or 3 deleted, respectively, were also expressed in human liver, lung, kidney and heart. In addition, ARΔ2Stop was expressed in rat and gilthead seabream …
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SS Laurentino, PIS Pinto, J Tomas, JE Cavaco… - Andrologia, 2013