作者
Julia Rohayem, Michael Zitzmann, Sandra Laurentino, Sabine Kliesch, Eberhard Nieschlag, Paul‐Martin Holterhus, Alexandra Kulle
发表日期
2021/1
期刊
Clinical Endocrinology
卷号
94
期号
1
页码范围
90-101
简介
Objective
To delineate the role of gonadotropins in male androgen biosynthesis pathways.
Design
Case‐control study.
Patients and measurements
Twenty five males with congenital hypogonadotropic hypogonadism (CHH) underwent hCG/rFSH and testosterone treatment sequentially. Serum steroid hormone profiles (testosterone precursors and metabolites) on both replacement regimens were analysed, using liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) and compared to those of healthy controls, matched by age, BMI and serum testosterone.
Results
On testosterone replacement, serum concentrations of the classic Δ4 pathway hormones progesterone and 17‐hydroxy‐progesterone (17‐OHP), and the marker steroid of an alternative pathway of testosterone synthesis (androstenediol) were decreased, compared to controls. Androstanediol, a marker of the backdoor pathway of …
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