作者
Lucas Miranda Kangussu, Vivian Vasconcelos Costa, Vania Claudia Olivon, Celso Martins Queiroz-Junior, Antônio Nei Santana Gondim, Marcos Barrouin Melo, Daniela Reis, Natália Nóbrega, Natália Araújo, Milene Alvarenga Rachid, Renan Pedra de Souza, Carlos Renato Tirapelli, Robson Augusto Souza Dos Santos, Jader dos Santos Cruz, Mauro Martins Teixeira, Danielle da Glória de Souza, Daniella Bonaventura
发表日期
2022/3/1
期刊
Heart
卷号
108
期号
5
页码范围
388-396
出版商
BMJ Publishing Group Ltd and British Cardiovascular Society
简介
Objective
Dengue fever is one of the most important arboviral diseases in the world, and its severe forms are characterised by a broad spectrum of systemic and cardiovascular hallmarks. However, much remains to be elucidated regarding the pathogenesis triggered by Dengue virus (DENV) in the heart. Herein, we evaluated the cardiac outcomes unleashed by DENV infection and the possible mechanisms associated with these effects.
Methods
A model of an adapted DENV-3 strain was used to infect male BALB/c mice to assess haemodynamic measurements and the functional, electrophysiological, inflammatory and oxidative parameters in the heart.
Results
DENV-3 infection resulted in increased systemic inflammation and vascular permeability with consequent reduction of systolic blood pressure and increase in heart rate. These changes were accompanied by a decrease in the cardiac output and stroke volume …
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LM Kangussu, VV Costa, VC Olivon… - Heart, 2022