作者
Michael Lefevre, Leanne M Redman, Leonie K Heilbronn, Julie V Smith, Corby K Martin, Jennifer C Rood, Frank L Greenway, Donald A Williamson, Steven R Smith, Eric Ravussin
发表日期
2009/3/1
期刊
Atherosclerosis
卷号
203
期号
1
页码范围
206-213
出版商
Elsevier
简介
Calorie restriction (CR) delays the development of age-associated disease and increases lifespan in rodents, but the effects in humans remain uncertain.
PURPOSE
Determine the effect of 6 months of CR with or without exercise on cardiovascular disease (CVD) risk factors and estimated 10-year CVD risk in healthy non-obese men and women.
METHODS
Thirty-six individuals were randomized to one of three groups for 6 months: Control, 100% of energy requirements; CR, 25% calorie restriction; CR+EX, 12.5% CR+12.5% increase in energy expenditure via aerobic exercise. CVD risk factors were assessed at baseline, 3 and 6 months.
RESULTS
After 6 months, CR and CR+EX lost approximately 10% of body weight. CR significantly reduced triacylglycerol (−31±15mg/dL) and factor VIIc (−10.7±2.3%). Similarly CR+EX reduced triacylglycerol (−22±8mg/dL) and additionally reduced LDL-C (−16.0±5.1mg/dL) and …
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