作者
Vanessa Cristina Santana, Bruna Magda Marmentini, Geórgia Guedes Cruz, Leila Camila de Jesus, Luana Walicheski, Fábio Henrique Beffa, Talles Henrique Pichinelli Maffei, Rafaela Vieira Streg, Valdir Florêncio Veiga-Junior, Carla Regina Andrighetti, Milena Campelo Freitas de Lima, Dênia Mendes de Sousa Valladão, Rithiele Cristina de Oliveira, Milton Omar Cordova Neyra, Rodolfo Cassimiro de Araújo Berber, Luiz Luciano Falconi-Sobrinho, Norberto Cysne Coimbra, Ricardo de Oliveira
发表日期
2024/3/12
期刊
Behavioural Brain Research
卷号
461
页码范围
114832
出版商
Elsevier
简介
Popular medicine has been using oleoresin from several species of copaíba tree for the treatment of various diseases and its clinical administration potentially causes antinociception. Electrical stimulation of ventrolateral (vlPAG) and dorsolateral (dlPAG) columns of the periaqueductal gray matter also causes antinociception. The aim this study was to verify the antinociceptive effect of oleoresin extracted from Copaifera langsdorffii tree and to test the hypothesis that oleoresin-induced antinociception is mediated by µ1- and κ-opioid receptors in the vlPAG and dlPAG. Nociceptive thresholds were determined by the tail-flick test in Wistar rats. The copaíba tree oleoresin was administered at different doses (50, 100 and 200 mg/kg) through the gavage technique. After the specification of the most effective dose of copaíba tree oleoresin (200 mg/kg), rats were pretreated with either the µ1-opioid receptor selective …
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VC Santana, BM Marmentini, GG Cruz, LC de Jesus… - Behavioural Brain Research, 2024