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Objectives. The purpose of this study was to determine the level of compassion fatigue in nurses caring for chronic diseases and the factors that affect it. Nurses who provide continuous care for chronic diseases are under the risk of facing compassion fatigue. Methods. The descriptive and cross-sectional study took place during January–March 2019. The nurse identification form and the ‘compassion fatigue’ sub-dimension of the professional quality of life scale were used to determine compassion fatigue. Results. Nurses experience compassion fatigue at a moderate level. Female nurses, those who experience a decrease in their willingness to provide care and those who intend to leave work experience compassion fatigue more. Decrease in the willingness to provide care plays a determinant role on compassion fatigue. Nurses who experience compassion fatigue are unwilling to provide care to their patients …