作者
Ralica Dimitrova, Maximilian Pietsch, Daan Christiaens, Judit Ciarrusta, Thomas Wolfers, Dafnis Batalle, Emer Hughes, Jana Hutter, Lucilio Cordero-Grande, Anthony N Price, Andrew Chew, Shona Falconer, Katy Vecchiato, Johannes K Steinweg, Olivia Carney, Mary A Rutherford, J-Donald Tournier, Serena J Counsell, Andre F Marquand, Daniel Rueckert, Joseph V Hajnal, Grainne McAlonan, A David Edwards, Jonathan O’Muircheartaigh
发表日期
2020/7/30
期刊
Cerebral Cortex
卷号
30
期号
9
页码范围
4800-4810
出版商
Oxford University Press
简介
Preterm-born children are at increased risk of lifelong neurodevelopmental difficulties. Group-wise analyses of magnetic resonance imaging show many differences between preterm- and term-born infants but do not reliably predict neurocognitive prognosis for individual infants. This might be due to the unrecognized heterogeneity of cerebral injury within the preterm group. This study aimed to determine whether atypical brain microstructural development following preterm birth is significantly variable between infants. Using Gaussian process regression, a technique that allows a single-individual inference, we characterized typical variation of brain microstructure using maps of fractional anisotropy and mean diffusivity in a sample of 270 term-born neonates. Then, we compared 82 preterm infants to these normative values to identify brain regions with atypical microstructure and relate observed deviations to …
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R Dimitrova, M Pietsch, D Christiaens, J Ciarrusta… - Cerebral Cortex, 2020