作者
Lianne Schmaal, DP Hibar, Philipp G Sämann, GB Hall, BT Baune, Neda Jahanshad, JW Cheung, Theo GM van Erp, Daniel Bos, Mohammad A Ikram, Meike W Vernooij, WJ Niessen, Henning Tiemeier, Albert Hofman, Katharina Wittfeld, Hans Jörgen Grabe, Deborah Janowitz, R Bülow, M Selonke, Henry Völzke, Dominik Grotegerd, Udo Dannlowski, Volker Arolt, Nils Opel, W Heindel, Harald Kugel, David Hoehn, Michael Czisch, Baptiste Couvy-Duchesne, Miguel E Rentería, Lachlan T Strike, Margaret J Wright, NT Mills, GI De Zubicaray, Katie L McMahon, Sarah E Medland, Nicholas G Martin, NA Gillespie, Roberto Goya-Maldonado, Oliver Gruber, Bernhard Krämer, SN Hatton, Jim Lagopoulos, IB Hickie, Thomas Frodl, A Carballedo, EM Frey, LS Van Velzen, Brenda WJH Penninx, Marie-José van Tol, NJ Van der Wee, CG Davey, BJ Harrison, Benson Mwangi, B Cao, Jair C Soares, IM Veer, Henrik Walter, D Schoepf, B Zurowski, C Konrad, E Schramm, Claudia Normann, Kerry Schnell, MD Sacchet, IH Gotlib, GM MacQueen, BR Godlewska, T Nickson, Andrew M McIntosh, Martina Papmeyer, HC Whalley, Jeremy Hall, Jessika E Sussmann, M Li, M Walter, L Aftanas, I Brack, NA Bokhan, Paul M Thompson, Dick J Veltman
发表日期
2017/6
期刊
Molecular psychiatry
卷号
22
期号
6
页码范围
900-909
出版商
Nature Publishing Group
简介
The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and …
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L Schmaal, DP Hibar, PG Sämann, GB Hall, BT Baune… - Molecular psychiatry, 2017