查看文章

To assess the cognitive training effectiveness on cognitive results in adults with a diagnosis of dementia and a mildmoderate level of severity. We developed specific search strategies for Ovid MEDLINE and EMBASE, among other databases. We included randomized controlled trials published in any language. Two independent reviewers performed the study selection and the extraction of the relevant data and assessed the risk of bias using the Cochrane Collaboration's Risk of Bias tool. A random-effects model meta-analysis of changes from baseline using standardized mean differences (SMD) was conducted. Subgroup analyses were performed. The GRADEPro tool was used to assess the quality of the evidence. 18 trials were included with a total of 1483 patients. The meta-analyses revealed that cognitive training, compared to a control group, may have large positive effects at end of treatment on overall cognitive function (SMD: 0.92; 95% CI 95% 0.35 to 1.48) and on delayed memory and language fluency in patients with mild-moderate dementia, as well as a more discrete positive effect on semantic (low-quality evidence). Moderate-quality evidence showed that cognitive training could have a moderate positive effect on the immediate memory (SMD: 0.69, 95% CI 0.42 to 0.97) and, in the medium term, on verbal fluency. Cognitive training may also be associated with a significant slower clinical progression of dementia (low-quality evidence). Cognitive training may be effective at improving overall cognitive function, memory and cognitive impairment progression in patients with mild to moderate …