作者
Gianluca Masi, Enrico Vasile, Fotios Loupakis, Samanta Cupini, Lorenzo Fornaro, Giacomo Baldi, Lisa Salvatore, Chiara Cremolini, Irene Stasi, Isa Brunetti, Maria Agnese Fabbri, Martina Puglisi, Patrizia Trenta, Cristina Granetto, Silvana Chiara, Luisa Fioretto, Giacomo Allegrini, Lucio Crinò, Michele Andreuccetti, Alfredo Falcone
发表日期
2011/1/5
期刊
Journal of the National Cancer Institute
卷号
103
期号
1
页码范围
21-30
出版商
Oxford University Press
简介
Background
In a randomized trial with a median follow-up of 18.4 months, 6 months of induction chemotherapy with a three-drug regimen comprising 5-fluorouracil (by continuous infusion)–leucovorin, irinotecan, and oxaliplatin (FOLFOXIRI) demonstrated statistically significant improvements in response rate, radical surgical resection of metastases, progression-free survival, and overall survival compared with 6 months of induction chemotherapy with fluorouracil–leucovorin and irinotecan (FOLFIRI).
Methods
From November 14, 2001, to April 22, 2005, we enrolled 244 patients with metastatic colorectal cancer. To evaluate if the superiority of FOLFOXIRI is maintained in the long term, we updated the overall and progression-free survival data to include events that occurred up to February 12, 2009, with a median follow-up of 60.6 months. We performed a subgroup and a risk …
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G Masi, E Vasile, F Loupakis, S Cupini, L Fornaro… - Journal of the National Cancer Institute, 2011