作者
Alessandro Russo, Marco Russano, Tindara Franchina, Maria R Migliorino, Giuseppe Aprile, Giovanni Mansueto, Alfredo Berruti, Alfredo Falcone, Michele Aieta, Alain Gelibter, Antonio Russo, Sandro Barni, Michele Maio, Olga Martelli, Francesco Pantano, Daniela Iacono, Lorenzo Calvetti, Silvia Quadrini, Elisa Roca, Enrico Vasile, Marco Imperatori, Mario Occhipinti, Antonio Galvano, Fausto Petrelli, Luana Calabrò, Giulia Pasquini, Salvatore Intagliata, Giuseppina RR Ricciardi, Giuseppe Tonini, Daniele Santini, Vincenzo Adamo
发表日期
2020/3
期刊
Advances in therapy
卷号
37
页码范围
1145-1155
出版商
Springer Healthcare
简介
Introduction
Immune checkpoint inhibitors have provided substantial benefit in non-small cell lung cancer (NSCLC) with unprecedented results in terms of survival. However, the identification of reliable predictive biomarkers to these agents is lacking and multiple clinicopathological factors have been evaluated. The aim of this study was to analyze the potential role of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lactate dehydrogenase (LDH) levels in patients with pretreated NSCLC receiving nivolumab.
Methods
This was a retrospective multicenter study involving 14 Italian centers, evaluating the role of some laboratory results in patients with NSCLC treated with nivolumab in the second or later lines of therapy for at least four doses and with a disease re-staging.
Results
A total of 187 patients with available pretreatment laboratory results were included. NLR levels below 5 were …
学术搜索中的文章
A Russo, M Russano, T Franchina, MR Migliorino… - Advances in therapy, 2020