作者
Lisanne J Balk, Danko Coric, Benjamin Knier, Hanna G Zimmermann, Raed Behbehani, Raed Alroughani, Elena H Martinez-Lapiscina, Alexander U Brandt, Bernardo Sánchez-Dalmau, Angela Vidal-Jordana, Philipp Albrecht, Valeria Koska, Joachim Havla, Marco Pisa, Rachel C Nolan, Letizia Leocani, Friedemann Paul, Orhan Aktas, Xavier Montalban, Laura J Balcer, Pablo Villoslada, Olivier Outteryck, Thomas Korn, Axel Petzold, IMSVISUAL consortium
发表日期
2019/9
期刊
Multiple Sclerosis Journal–Experimental, Translational and Clinical
卷号
5
期号
3
页码范围
2055217319871582
出版商
Sage Publications
简介
Background
The association of peripapillary retinal nerve fibre layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness with neurodegeneration in multiple sclerosis (MS) is well established. The relationship of the adjoining inner nuclear layer (INL) with inflammatory disease activity is less well understood.
Objective
The objective of this paper is to investigate the relationship of INL volume changes with inflammatory disease activity in MS.
Methods In this longitudinal, multi-centre study, optical coherence tomography (OCT) and clinical data (disability status, relapses and MS optic neuritis (MSON)) were collected in 785 patients with MS (68.3% female) and 92 healthy controls (63.4% female) from 11 MS centres between 2010 and 2017 and pooled retrospectively. Data on pRNFL, GCIPL and INL were obtained at each centre.
Results
There was a significant increase in INL volume in eyes with new MSON …
学术搜索中的文章
LJ Balk, D Coric, B Knier, HG Zimmermann… - Multiple Sclerosis Journal–Experimental, Translational …, 2019