作者
Bang Zheng, Amelia CA Green, John Tazare, Helen J Curtis, Louis Fisher, Linda Nab, Anna Schultze, Viyaasan Mahalingasivam, Edward PK Parker, William J Hulme, Sebastian CJ Bacon, Nicholas J DeVito, Christopher Bates, David Evans, Peter Inglesby, Henry Drysdale, Simon Davy, Jonathan Cockburn, Caroline E Morton, George Hickman, Tom Ward, Rebecca M Smith, John Parry, Frank Hester, Sam Harper, Amir Mehrkar, Rosalind M Eggo, Alex J Walker, Stephen JW Evans, Ian J Douglas, Brian MacKenna, Ben Goldacre, Laurie A Tomlinson
发表日期
2022/11/16
期刊
bmj
卷号
379
出版商
British Medical Journal Publishing Group
简介
Objective
To compare the effectiveness of sotrovimab (a neutralising monoclonal antibody) with molnupiravir (an antiviral) in preventing severe outcomes of covid-19 in adult patients infected with SARS-CoV-2 in the community and at high risk of severe outcomes from covid-19.
Design
Observational cohort study with the OpenSAFELY platform.
Setting
With the approval of NHS England, a real world cohort study was conducted with the OpenSAFELY-TPP platform (a secure, transparent, open source software platform for analysis of NHS electronic health records), and patient level electronic health record data were obtained from 24 million people registered with a general practice in England that uses TPP software. The primary care data were securely linked with data on SARS-CoV-2 infection and treatments, hospital admission, and death, over a period when both drug treatments were frequently prescribed in …
学术搜索中的文章
B Zheng, ACA Green, J Tazare, HJ Curtis, L Fisher… - Bmj, 2022