作者
Jiang, Collins, Benson
发表日期
1999/10
期刊
British journal of clinical pharmacology
卷号
48
期号
4
页码范围
635-637
出版商
Blackwell Science Ltd
简介
Aims Topical sunscreens are routinely applied to the skin by a large percentage of the population. This study assessed the extent of absorption of a number of common chemical sunscreen agents into and through human skin following application of commercially available products.
Methods Sunscreen products were applied to excised human epidermis in Franz diffusion cells with the amount penetrating into and across the epidermis assessed by h.p.l.c. for 8 h following application.
Results All sunscreen agents investigated penetrated into the skin (0.25 g m−2 or 14% of applied dose), but only benzophenone‐3 passed through the skin in significant amounts (0.08 g m−2 or 10% of the applied dose). With one exception, suncreen agents in corresponding products marketed for adults and children had similar skin penetration profiles.
Conclusions Whilst limited …
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