作者
Hubert Cochet, Rémi Dubois, Seigo Yamashita, Nora Al Jefairi, Benjamin Berte, Jean-Marc Sellal, Darren Hooks, Antonio Frontera, Sana Amraoui, Adlane Zemoura, Arnaud Denis, Nicolas Derval, Frederic Sacher, Olivier Corneloup, Valérie Latrabe, Stéphanie Clément-Guinaudeau, Jatin Relan, Sohail Zahid, Patrick M Boyle, Natalia A Trayanova, Olivier Bernus, Michel Montaudon, François Laurent, Mélèze Hocini, Michel Haïssaguerre, Pierre Jaïs
发表日期
2018/1
期刊
JACC: Clinical Electrophysiology
卷号
4
期号
1
页码范围
17-29
出版商
American College of Cardiology Foundation
简介
Objectives
This study sought to assess the relationship between fibrosis and re-entrant activity in persistent atrial fibrillation (AF).
Background
The mechanisms involved in sustaining re-entrant activity during AF are poorly understood.
Methods
Forty-one patients with persistent AF (age 56 ± 12 years; 6 women) were evaluated. High-resolution electrocardiographic imaging (ECGI) was performed during AF by using a 252-chest electrode array, and phase mapping was applied to locate re-entrant activity. Sites of high re-entrant activity were defined as re-entrant regions. Late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR) was performed at 1.25 × 1.25 × 2.5 mm resolution to characterize atrial fibrosis and measure atrial volumes. The relationship between LGE burden and the number of re-entrant regions was analyzed. Local LGE density was computed and characterized at re-entrant sites. All patients …
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H Cochet, R Dubois, S Yamashita, N Al Jefairi, B Berte… - JACC: Clinical Electrophysiology, 2018
H Cochet, R Dubois, S Yamashita, N Al Jefairi, B Berte… - JACC: Clinical Electrophysiology, 2017