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Introduction: We hypothesized that the frequency spectra of fibrillatory electrograms may reflect the complexity of activities perpetuating atrial fibrillation (AF). To test this hypothesis, we evaluated the frequency spectra in patients with paroxysmal AF in relation to catheter ablation.

Methods and Results: This study comprised two protocols: 25 patients undergoing pulmonary vein (PV) isolation in protocol I, and 20 patients undergoing mitral isthmus linear ablation after PV isolation in protocol II. The mean of dominant frequency (DF) and organization index (the ratio of the area under the DF and its harmonics to the total power) were determined from 32‐second recordings in the coronary sinus. In protocol I, a PV was considered “driver” of AF if isolation of the PV resulted in termination or slowing of AF (decrease in DF by ≥0.25 Hz). Twenty‐one patients had AF termination during four PV isolation. Among these 21 …