作者
Ji Young Hong, Hye Jon Lee, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Sang-Nae Cho, Young Ae Kang
发表日期
2014/3/1
期刊
Journal of Infection
卷号
68
期号
3
页码范围
252-258
出版商
WB Saunders
简介
Objectives
IP-10 has been proposed as a promising alternative marker for the diagnosis of tuberculosis (TB).
Methods
In this exploratory study, we assessed the levels of serum IP-10 and TB antigen-dependent IP-10 at the time of diagnosis and after completing treatment in 32 patients with active TB.
Results
Significant changes in concentration between the time of diagnosis and the completion of therapy were observed for serum IP-10 (P < 0.001; median: 140.4 and 105.7 pg/ml, respectively) and TB antigen-dependent IP-10 (P = 0.002; median: 20,000 and 13,720 pg/ml, respectively). The proportion of TB antigen-dependent IP-10 responders did not change significantly between baseline and the completion of therapy (P = 0.35), whereas the proportion of serum IP-10 responders was significantly different (P = 0.001).
Conclusions
Serum IP-10 and TB antigen-dependent IP-10 responses to QFT-GIT antigens might be a …
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