作者
Byung Hoon Park, Young Ae Kang, Moo Suk Park, Won Jai Jung, Su Hwan Lee, Sang Kook Lee, Song Yee Kim, Se Kyu Kim, Joon Chang, Ji Ye Jung, Young Sam Kim
发表日期
2011/12
期刊
BMC infectious diseases
卷号
11
页码范围
1-9
出版商
BioMed Central
简介
Background
The immature granulocyte count has been reported to be a marker of infection and sepsis. The difference in leukocyte subfractions (delta neutrophil index, DNI) in ADVIA 2120 reflects the fraction of circulating immature granulocytes in the blood. This study evaluated the clinical utility of DNI as a severity and prediction marker in critically ill patients with sepsis.
Methods
One hundred and three patients admitted to the medical intensive care unit with sepsis were studied. DNI (the difference in leukocyte subfractions identified by myeloperoxidase and nuclear lobularity channels) was determined using a specific blood cell analyzer.
Results
Forty four patients (42.7%) were diagnosed with severe sepsis/septic shock. Overt disseminated intravascular coagulation (DIC) occurred in 40 (38.8%). DNI was significantly …
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