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The present work aimed to estimate the phytochemical profile and antimicrobial activity of medicinal plant Ruellia patula (L.) against human pathogenic bacteria. Medicinal plants are the effective source for the development of drug against several diseases. Nowadays, medicinal plants were used to treat most diseases among humans because of its medicinal value. In Ayurveda and Siddha, many medicinal plants have been recommended for the management of common diseases. The extraction was done by using different solvent such as ethanol, methanol and acetone by using standard procedures. The antibacterial assay was carried by using agar well method with different organisms and also antifungal activity against Aspergillus niger using disc diffusion method. The ethanolic extract of R. patula L.(0.4 mg/mL) showed higher antibacterial activity against Gram positive bacteria and Gram negative bacteria. In the antifungal activity also ethanolic extract shows highest activity compare to other extract. From the present work, we conclude that the ethanolic extract of plant R. patula L. have potential of antibacterial activity and antifungal activity because of its secondary metabolites in the plant which responsible for biological activities. Due to the presence of phyto-constituent in the plant extract may control the bacterial growth either in high concentration/long durations and it may have the ability to control the human pathogenic organisms.