作者
Timothy Paape, Peng Zhou, Antoine Branca, Roman Briskine, Nevin Young, Peter Tiffin
发表日期
2012/1/1
期刊
Genome biology and evolution
卷号
4
期号
5
页码范围
726-737
出版商
Oxford University Press
简介
Recombination rates vary across the genome and in many species show significant relationships with several genomic features, including distance to the centromere, gene density, and GC content. Studies of fine-scale recombination rates have also revealed that in several species, there are recombination hotspots, that is, short regions with recombination rates 10–100 greater than those in surrounding regions. In this study, we analyzed whole-genome resequence data from 26 accessions of the model legume Medicago truncatula to gain insight into the genomic features that are related to high- and low-recombination rates and recombination hotspots at 1 kb scales. We found that high-recombination regions (1-kb windows among those in the highest 5% of the distribution) on all three chromosomes were significantly closer to the centromere, had higher gene density, and lower GC content than low …
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