作者
Adam E Handel, Alexander J Williamson, Giulio Disanto, Lahiru Handunnetthi, Gavin Giovannoni, Sreeram V Ramagopalan
发表日期
2010/9/1
期刊
PloS one
卷号
5
期号
9
页码范围
e12496
出版商
Public Library of Science
简介
Background
Multiple sclerosis (MS) appears to develop in genetically susceptible individuals as a result of environmental exposures. Epstein-Barr virus (EBV) infection is an almost universal finding among individuals with MS. Symptomatic EBV infection as manifested by infectious mononucleosis (IM) has been shown in a previous meta-analysis to be associated with the risk of MS, however a number of much larger studies have since been published.
Methods/Principal Findings
We performed a Medline search to identify articles published since the original meta-analysis investigating MS risk following IM. A total of 18 articles were included in this study, including 19390 MS patients and 16007 controls. We calculated the relative risk of MS following IM using a generic inverse variance with random effects model. This showed that the risk of MS was strongly associated with IM (relative risk (RR) 2.17; 95% confidence interval 1.97–2.39; p<10−54).
Discussion
Our results establish firmly that a history of infectious mononucleosis significantly increases the risk of multiple sclerosis. Future work should focus on the mechanism of this association and interaction with other risk factors.
学术搜索中的文章
AE Handel, AJ Williamson, G Disanto, L Handunnetthi… - PloS one, 2010