作者
Jessica Wojtaszek, Jiangxin Liu, Sanjay D'Souza, Su Wang, Yaohua Xue, Graham C Walker, Pei Zhou
发表日期
2012/7/27
期刊
Journal of Biological Chemistry
卷号
287
期号
31
页码范围
26400-26408
出版商
Elsevier
简介
Background: Translesion synthesis requires the scaffolding function of the Rev1 CTD.
Results: We determined the structures of the Rev1 CTD and its complex with Pol κ and mapped its Rev7-binding surface.
Conclusion: Distinct surfaces of the Rev1 CTD separately mediate the assembly of extension and insertion translesion polymerase complexes.
Significance: Cancer therapeutics could be developed by inhibiting Rev1 CTD-mediated translesion synthesis.
学术搜索中的文章
J Wojtaszek, J Liu, S D'Souza, S Wang, Y Xue… - Journal of Biological Chemistry, 2012