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Background:

The aim of this study was to investigate the role of oxidative stress in the pathology of ovine dicrocoeliasis.

Methods:

During Dec 2013–Oct 2014, seventy-two sheep (1–3 years) with liver dicrocoeliasis along with 47 healthy sheep were selected from animals admitted for slaughtering at slaughterhouse located in Neyshabour, Razavi Khorasan Province, Iran.

Results:

In comparison to healthy control, the malondialdehyde (MDA) level and serum total antioxidant capacity were significantly higher in the parasitized group (P< 0.05). A significant increase in liver MDA concentration (P< 0.05) of parasitized group was also observed. Packed cell volume (PCV), zinc, iron, total bilirubin and albumin sera levels were significantly lower in the parasitized group (P< 0.05). In parasitized sheep, a significant positive correlation was seen between serum MDA concentration and the activity of aspartate aminotransferase …