查看文章

Although annular fibrosis is the hallmark of cirrhosis, other microscopic changes that affect liver function such as sinusoid capillarization or loss of metabolic zonation are common. A sustained virological response (SVR) may halt fibrosis deposition in hepatitis C virus (HCV)‐infected patients, but its impact on the other cirrhosis‐associated lesions is unknown. The aim of this study was to assess the impact of an SVR on cirrhosis‐related histopathological features. Paired pre‐ and posttreatment liver biopsies from 38 HCV patients with cirrhosis with an SVR were analyzed. Fibrosis was staged using the METAVIR scoring system, and the area of fibrosis was measured using morphometry. Ductular proliferation, metabolic zonation, sinusoid capillarization, and hepatic stellate cell activation were assessed by anti‐cytokeratin‐7, anti‐glutamine synthetase (GS), anti‐cytochrome P4502E1 (CYP2E1), anti‐CD34, and anti α …